Polygenic quantitative traits for Alzheimer and Related Pathologies

 
   Lead Investigator:    Corey McMillan
   Institution      :    University of Pennsylvania
   E-Mail           :    mcmillac@pennmedicine.upenn.edu
   Proposal ID      :    1504



   Proposal Description:
   The goal of this project is to relate previous meta-statistics derived from neuropathology and other association studies to tau, amyloid, Lewy body, and TDP-43 pathological load.  We then plan to cluster individuals based on several polygenic scores to identify genetic subgroups for those at risk for PART, AD, LATE and related disorders.